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The Broad Institute
Cambridge, MA, United States (on-site)
15 days ago
Member Company
The Broad Institute
Cambridge, MA, United States (on-site)
15 days ago


The Genetic Perturbation Platform (GPP) of the Broad Institute of MIT and Harvard, formerly the Broad RNAi Platform is looking for an exceptional candidate to develop and employ technologies for gene function discovery.

The GPP is a worldwide leader in functional annotation of the genome. We pioneer functional genomics technologies and methodologies as well as their application to biological discovery. We collaborate with researchers in fields ranging from infectious disease and stem cell biology to psychiatric disease and cancer, illustrating the incredible demand for innovation in functional genomics in all areas of biology. The Broad Institute is a vibrant research environment with close links to top academic institutions and hospitals across the Boston area and provides the potential for contributions to be used and recognized worldwide. The people, the resources, and the culture of the Broad enable cross-cutting approaches to our most important biological problems and therapeutic challenges. 

The successful candidate will lead projects in GPP to develop and to implement technologies for functional genomics in mammalian cells.  There is a current focus on CRISPR technologies and applications, as well as other new technologies and also more mature approaches such as gene over expression whose utility could be extended. The candidate will also take the lead in advising and assisting collaborators in functional genomics screening projects in a broad range of biological and biomedical areas, and in deploying GPP resources for these projects.  The candidate will help to identify challenges and limitations in functional genomics practice and technologies, and will design and perform experiments to address these challenges with support of research associates. Over time, the candidate will be encouraged to develop more independent research projects. The successful candidate will have the opportunity to make impactful contributions in a fast-paced and dynamic research environment at the cutting edge of biomedical research.



  • Designs, plans, and execute platform research projects, working in close collaboration with other senior scientific staff. Plans, schedules, and coordinates detailed phases of projects. Identifies and resolves technical problems
  • Lead Genetic Perturbation Platform role in collaborative screening projects. Provide guidance on all phases of screens including contributions to all phases: design, assay development, experimental execution, data analysis. Interact with investigators in many areas of biology to launch and guide collaborative work.
  • Present work at group meetings, Broad seminars, partner meetings including the Functional Genomics Consortium meetings, and conferences.
  • Makes significant contributions to scientific papers; is a resource/ author/ co-author for reports and presentations, participates in the writing of grant proposals.
  • Attend meetings at Broad to learn about other science at the Broad, and to represent the Genetic Perturbation Platform.


  • PhD in Biology or similar field
  • 4+ years of experience in relevant biological research


  • Expert in mammalian cell culture, including challenging cell-based models.
  • Experience with various cell-based assays and larger-scale cell-based screens
  • Knows standard molecular biology techniques.
  • Experience in the application of lentiviral vectors.
  • Strong written and data-presentation skills.
  • Self-motivated and curious experimentalist.
  • Supportive and respectful teammate.
  • Some coding skills in R, Python, or similar.

Job Information

  • Job ID: 64492587
  • Workplace Type: On-Site
  • Location:
    Cambridge, MA, United States
  • Position Title: Senior Research Scientist I - Genetic Perturbation Platform (GPP)
  • Company Name For Job: The Broad Institute
  • Job Function: Drug Discovery
  • Job Type: Full-Time
  • Job Duration: Indefinite
  • Min Education: Ph.D.
  • Min Experience: 3-5 Years
  • Required Travel: None
  • Salary: $115.00 - $125.00 (Yearly Salary)

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