Job Function: Drug Discovery
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Jnana Therapeutics
Massachusetts, United States (hybrid)
24 days ago
Massachusetts, United States (on-site)
25 days ago
Jnana Therapeutics
Massachusetts, United States
Member Company
24 days ago
Job Type
Job Duration
Min Education
Work Setting
Job Function
Drug Discovery


About Us

Jnana Therapeutics is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet needs. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, including rare diseases and immune-mediated diseases. Jnana’s wholly owned lead program, JNT-517, which targets an allosteric site on the phenylalanine transporter SLC6A19, is a potential first-in-class oral approach for the treatment of PKU, a rare genetic metabolic disease. Located in Boston, Jnana brings together scientific leaders in small molecule drug discovery and development, a highly experienced management team, and the backing of leading life science investors Bain Capital Life Sciences, RA Capital Management, Polaris Partners, Versant Ventures, Avalon Ventures, Pfizer Ventures, and AbbVie Ventures. For more information, please visit and follow us on Twitter/X and LinkedIn.

About the Opportunity

Jnana Therapeutics is seeking an exceptional Director/Senior Director, Head of Chemical Computing Sciences to join our internal chemistry group focused on drug discovery programs for hard-to-drug targets. This individual will play a critical role in developing our platform and executing on drug discovery programs. Through small molecule screening using our novel and proprietary chemoproteomics RAPID platform, our research aims to identify novel small molecules against these challenging targets – to interrogate target biology and ultimately to develop drug candidates that can provide clinical value to patients. 


  • Develop and implement a computational chemistry strategy to support small molecule drug discovery and development
  • Lead all efforts in computational chemistry and chemoinformatics
  • Provide mentorship to a talented group of computational chemists and chemical informaticists
  • Provide key strategic input and also execution on structure-based drug design programs
  • Be able to apply and interpret the results of modern computational tools (molecular dynamics/FEP) for our structurally enabled programs
  • Build and expand Jnana internal computational chemistry capabilities
  • Collaborate with internal project teams to establish a computational chemistry strategy
  • As part of the Research Leadership team, serve as a thought leader and subject matter expert across scientific disciplines on multiple projects


Desired Qualifications & Past Experience

  • Ph.D and post-doctoral experience in Computational Chemistry with at least 10 years of industry experience successfully leading computational chemistry efforts from Hit-to-Lead and into clinical development
  • Strong commitment to excellence and passion for drug discovery and development
  • Highly organized, detailed-oriented with excellent communication skills and passion for working in multidisciplinary teams
  • Demonstrated track-record of mentoring, developing and leading direct reports
  • Ability to be onsite at our Seaport office
Job ID: 72282903

Please refer to the company's website or job descriptions to learn more about them.

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