Description

About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit www.morphictx.com.

Morphic is advancing both partnered and fully-owned oral integrin therapeutic candidates with the initial clinical trials beginning in 2020. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept. Morphic Therapeutic is located in the BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, integrity, and beauty.

Job Description:

The Principal/Senior Scientist, Translational Sciences will have a passion for biomarker discovery and a demonstrable track record in this space and will contribute to biomarker discovery by proposing novel biomarkers based on the best available science. This candidate will support translational studies in multiple therapeutic programs and develop understanding of compound mechanism of action and delineate translational biomarkers using in vivo/ex vivo rodent models. The Principal/Senior Scientist will have experience with ex vivo human model systems for biomarker discovery/validation and mechanism of action studies, and be familiar with multiple assay platforms (e.g. RNA seq, proteomics).

RESPONSIBILITIES (includes but not limited to):

• Display Morphic core values of compassion, craftsmanship, tenacity, teamwork, integrity, and

beauty

• Design, plan, execute and analyze tissue based and/or animal experiments to assess in vivo efficacy, biomarker, safety, and PK/PD profiles of small molecule therapeutics to move programs from discovery to clinical development.

• Initiate and oversee collaborations with internal/external collaborators and CROs.

• Develop in-house capabilities to support work performed at CROs.

• Lead and/or participate in multiple projects within discovery and translation, provide scientific expertise, guidance, and strategy to successfully progress programs to various milestones.

• Partner with additional experts within Morphic as well as across project teams to advance programs in the pipeline.

• Provide updates and advice to project teams, including evaluation of data and their potential impact on drug programs and clinical/regulatory strategy.

• Effectively communicate experimental findings in oral, written, and visual formats.

• Work independently and collaboratively in a multidisciplinary team environment.

QUALIFICATIONS:

• Ph.D. with focus in pharmacology/immunology/cell biology with 6+ years of relevant postdoctoral or industry experience

• Flexible, collaborative, and able to thrive in a fast-paced biotech environment

• Expertise in one or more of the following therapeutic areas: inflammation, cardiopulmonary disease, or fibrosis

• Technical understanding across broad protein biomarker assays including histopathology, ELISA, MSD, IHC, and flow cytometry

• Experience in multiple omics platforms

• Established track record of scientific excellence including publications and presentations at conferences

• Experience managing and leading scientific teams with a commitment to career support of team members

• Direct experience in outsourcing and validation of biomarker assays and clinical protocol and study report preparation

PREFERRED:

• Awareness of regulatory requirements and experience working central labs and CLIA certified labs

• Extensive experience with tissue processing and ex vivo analytical assays such as IFA, IHC, ELISA, Western, qPCR, flow cytometry etc.

• Expertise in the use multiple omics methodologies and analysis of their data output

• Experience with various mouse and rat models of dise~ses

• Experience working within large pharrna organizations and/or biotech/start up environment

• Experience in managing external partners (CRO & academic groups)

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.