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Scientist / Sr. Scientist: Antibody Engineering

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Manifold Bio
Boston, Massachusetts, United States (on-site)
30 days ago


Scientist / Sr. Scientist: Antibody Engineering

Manifold Bio is a biotechnology company aiming to revolutionize the development of protein therapeutics through multiplexed testing and design. We are building a platform distinguished by a novel technology that brings multiplexed measurement to every step of protein engineering, including in vivo testing. We recently raised a $40 million Series A and we are expanding our highly collaborative and interdisciplinary team. With this new round of funding, we will leverage our platform to generate an unprecedented amount of in vivo data allowing us to precisely engineer drugs with substantially less clinical risk. Our founders come from George Church’s lab at Harvard Medical School and are innovators in leveraging DNA and protein multiplexing technologies to engineer biological systems. We are located in the Pagliuca Harvard Life Lab and are moving into our own lab space in Boston at the end of the year.


Manifold Bio is seeking an enthusiastic, creative scientist to join our growing team in our mission of multiplexed, in vivo drug discovery. The ideal candidate will have extensive experience in protein engineering and protein therapeutic design. This is a unique opportunity to own impactful projects and play a big role on a small team looking to redefine current drug discovery paradigms. You will play an integral part in every step of our programs’ work, from designing initial binder campaigns to reformatting hits, advancing candidates through screening funnels, and nominating candidates for clinical development. In particular, you will make use of high-throughput and library methods both in vitro and, uniquely, in vivo using Manifold’s proprietary protein barcoding technology.

You will work closely with a collaborative, interdisciplinary team of scientists to design, execute, and analyze complex experiments in a fast-paced environment. There will be many opportunities for creativity, innovation, and ownership in this hands-on role leveraging our cutting edge platform to initiate and advance programs. Together, we’ll continue to build a transformational company based on the original vision of massively increasing the throughput of testing of protein therapeutic designs to fundamentally change the current paradigm of drug development.


  • Independently design, plan and execute experiments to advance drug candidates and programs
  • Assume ownership of protein engineering efforts for at least one drug program
  • Build on current binder discovery and screening pipelines to increase throughput and efficiency
  • Balance responsibilities across initiating and advancing programs and pursuing long-term innovation projects
  • Contribute to lead validation experiments and prepare preclinical data packages
  • Stay up to speed on cutting edge research and industry standards for protein therapeutics
  • Maintain data integrity and effectively communicate findings to the team


Required Qualifications

  • PhD in protein biochemistry, molecular biology, cell biology, bioengineering or similar; or B.S./M.S. with at least 4 years experience
  • Hands on expertise in protein engineering with a libraries/selections/multiplexing/empirical approach
  • Established experience in advanced cloning techniques
  • Proven track record of solving difficult scientific problems
  • Collaborative, curious, and flexible, with a genuine passion for innovative science and developing medicines

Preferred Qualifications

  • PhD with 3+ years experience in pharma/biotech industry working on protein or cell-based drug program(s)
  • Expertise in protein engineering in the context of antibody constructs, single-domain antibodies, or similar
  • Experience in designing libraries for binder campaigns, epitope selection, choice of format, linker design, avidity engineering, structure-guided engineering, etc.
  • Experience with yeast display or other display technology i.e. phage display, mammalian display or ribosome display
  • Experience in designing and running high throughput screening assays
  • Experience with CAR-T, T-cell engagers, multi-specifics, ADCs, targeted cytokines, or other ‘targeted-effector’ modalities
  • Knowledge of cell biology and cancer biology is a plus

Why you might be a good fit

  • Highly independent, productive, and creative scientist able to confront obstacles to drive projects forward
  • Team player with enthusiasm for working closely with a tight-knit team on challenging problems
  • Strong oral and written communication to facilitate complex experiments with multiple parties; excellent record keeping
  • Forethought, organization, and flexibility to meet deadlines and iterate in a fast-paced environment

If you’re excited to build a platform that combines DNA and protein multiplexing technologies, please reach out to

We value different experiences and different ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.

Job Information

  • Job ID: 65374692
  • Workplace Type: On-Site
  • Location:
    Boston, Massachusetts, United States
  • Position Title: Scientist / Sr. Scientist: Antibody Engineering
  • Company Name For Job: Manifold Bio
  • Job Function: Scientist
  • Job Type: Full-Time
  • Min Education: BA/BS/Undergraduate
  • Min Experience: 3-5 Years
Boston , Massachusetts , United States

Manifold Bio is a fully-integrated biotechnology company pursuing a pipeline of targeting-enhanced protein therapeutics. We have built a platform distinguished by a novel proteomics technology that brings pooled measurement to every step of protein engineering, including in vivo testing. This gives us an unmatched advantage in engineering precise targeting, critical to unlocking the potential of entire classes of drugs. Our team is highly collaborative and interdisciplinary. We are located in the Pagliuca Harvard Life La...

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